Date: Thu, 18 Dec 1997 17:53:14 GMT Server: Apache/1.2.4 Last-Modified: Thu, 30 Oct 1997 19:29:50 GMT ETag: "9ae2-d13-3458e02e" Content-Length: 3347 Accept-Ranges: bytes Connection: close Content-Type: text/html TVI_System

TVI System

An interesting aspect of AAV is that it integrates into a specific location on chromosome 19. This property is attributed to one of the components of the AAV, the Rep protein. In an AAV vector, all viral genes including the gene for Rep are removed, thereby reducing or eliminating the ability of the vector to integrate into the cell genome. However, for applications where integration is necessary in order to pass the gene to off-spring cells, Avigen has developed the TVI system. This system consists of the Rep protein and the gene cassette and can be delivered in a variety of vector systems, retaining the site specific integration into chromosome 19. This is important to its safety profile because random DNA integration has the risk of activating undesired genes such as oncogenes or inactivating desired genes on the cell genome.

Avigen TVI Gene Delivery System

Another advantage of TVI is that if used with appropriate delivery system such as non-viral vectors, it allows for the delivery of large gene sequences. Delivering large segments of DNA is important for gene therapy applications that require several genes or regulatory elements. This is becoming increasingly important as the field of gene therapy begins to address the problems of gene regulation and tissue specific expression, as well as the treatment of common diseases which require multiple genes.


HomePageWhatsNewAAV VectorsNasdaq-AVGNEmploymentCorporate PartnersTable of Contents